CBD for Animals

CBD oil for dogs and cats

As animal lovers, we see animals all the time, we enjoy them, we care for them, we relax around them, they are our friends. That's why we do our best to take care of them, to keep them healthy and well. For these reasons, animal keepers are increasingly turning to natural hemp products with CBD.

CBD is cannabidiol, found naturally in hemp.

How does CBD benefit your dog and cat?

Your pet has an endocannabinoid system, just like a human. It is a complex system of cellular signalling that was only discovered in the early 1990s by scientists studying the cannabinoid tetrahydrocannabinol, THC, which is naturally found in hemp. 

The endocannabinoid system is still undergoing research to understand how it works, but it is well known that it plays an important role in regulating a wide range of functions and processes such as sleep, mood, appetite, memory and fertility. [1] The endocannabinoid system is present and actively involved in your body's functions even if you do not consume cannabis products.

CBD acts on the endocannabinoid system by stimulating the nervous, digestive and immune systems and the brain. In this way, CBD can help relieve pain, nausea and other symptoms of indigestion. That's why CBD can benefit your pet.

Joint problems. If your dog or cat suffers from joint pain, your vet may prescribe painkillers, but all chemical drugs have side effects and can adversely affect your dog or cat's joints and soft tissues, damaging the liver, kidneys or the like. In contrast, CBD oil is a natural remedy that does not have the side effects of some medications. CBD oil works by influencing the endocannabinoid system, which stimulates the immune system to reduce inflammation, as well as altering the brain's response to pain. Researchers at Cornell University have found that dogs that took 2mg/kg of CBD oil twice a day for osteoarthritis were more active and had less pain[2].

Cancer. Unfortunately, this is still very much the case. Cancer researchers are constantly looking for new ways to treat cancer and reduce the pain and nausea caused by chemotherapy or radiation. CBD has been studied quite extensively as a medicine that can cure cancer. Studies have shown that CBD use slowed the growth of mammary gland cancer cells, increased the survival rate of mice with pancreatic cancer, slowed the growth of tumours, increased the effectiveness of traditional cancer treatments, CBD killed cancer cells by preventing them from feeding, and CBD activates the immune system. [3;4;5;6;7;8] CBD can help with nausea caused by treatments, and can also reduce pain[9; 10].

Seizures and epilepsy. Epilepsy in dogs, cats and humans is a complex brain disease with a long-term tendency to cause recurrent epileptic seizures. Your veterinarian can prescribe anticonvulsant drugs, but these are not always helpful, and they also cause a variety of side effects, damaging the liver and other organs. Researchers were surprised to find that CBD use in dogs reduced seizures by as much as 89%. In human studies, CBD even worked on forms of epilepsy that are resistant to marketed drugs. As a result, a human anticonvulsant drug based on CBD has been developed and marketed. It has been successful in reducing epileptic seizures in humans. [11; 12;13;14; 15]

Anxiety or stress. Just like humans, dogs and cats are stressed by certain changes, it's inevitable. Anxiety comes in many forms, such as: fear of sounds and other familiar stimuli, separation, avoidance of attention, aggression.

CBD oil is an excellent anti-anxiety and insomnia remedy, even for children with post-traumatic stress disorder (PTSD). CBD's biggest advantage is that it has no dangerous side effects. [16; 17]

Pain. Just like our pets, we all experience pain in one way or another. CBD works well to inhibit pain perception by binding to receptors in the brain and nervous system, and can also reduce inflammation and manage acute pain after injury. [18]

Allegria. It spreads not only between people, but also between dogs and cats, which is very difficult to treat. Skin lesions are a serious enough reason to visit the vet. CBD can also help to deal with this problem, as the skin also contains an endocannabinoid system that is affected by cannabidiol. It can help to reduce dryness and itchiness and stimulate the growth of new healthy skin cells.

Lipopolysaccharide (LPS). Italian scientists have provided the first evidence of CBD's ability to reduce the inflammation caused by STDs in a scientific study published in September 2021. This discovery certainly encourages further research into the therapeutic role of CBD in veterinary medicine. [19]

So CBD can help your pet in many ways, but we suggest you choose only quality products, However, the use of CBD oil is not regulated in the EU, so you need to be very careful not to be deceived when choosing a product.

Magu Space offers you just such a product - a quality CBD oil for animals that can help your pet feel better. It is a full spectrum CBD oil, laboratory tested, extracted and GMP certified. Be sure to check with your veterinarian for use.

Sources:

[1] "A Simple Guide to the Endocannabinoid System" Medical Review by Alan Carter, Pharm.D. - Written by Crystal Raypole  https://www.healthline.com/health/endocannabinoid-system

[2] "Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs" Lauri-Jo Gamble, Jordyn M. Boesch, Christopher W. Frye, Wayne S. Schwark, Sabine Mann, Lisa Wolfe, Holly Brown5, Erin S. Berthelsen and Joseph J. Wakshlag  https://www.frontiersin.org/articles/10.3389/fvets.2018.00165/full

[3] "Cannabidiol in cancer treatment" Rudolf Likar, Markus Köstenberger, Gerhard Nahler https://pubmed.ncbi.nlm.nih.gov/31897700/

[4] "Cannabidiol (CBD) as a Promising Anti-Cancer Drug" Emily S Seltzer, Andrea K Watters, Danny MacKenzie Jr, Lauren M Granat, Dong Zhang https://pubmed.ncbi.nlm.nih.gov/33143283/

[5] "Oral medicinal cannabinoids to relieve symptom burden in the palliative care of patients with advanced cancer: a double-blind, placebo-controlled, randomised clinical trial of efficacy and safety of cannabidiol (CBD)" Phillip Good, Alison Haywood, Gauri Gogna, Jennifer Martin, Patsy Yates, Ristan Greer, Janet Hardy https://pubmed.ncbi.nlm.nih.gov/31810437/

[6] "Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer" Brigitta Kis, Feng Chen Ifrim, Valentina Buda, Stefana Avram, Ioana Zinuca Pavel, Diana Antal, Virgil Paunescu, Cristina Adriana Dehelean, Florina Ardelean, Zorita Diaconeasa, Codruta Soica, Corina Danciu https://pubmed.ncbi.nlm.nih.gov/31775230/

[7] "Cannabidiol (CBD) in Cancer Management" Kylie O'Brien  https://pubmed.ncbi.nlm.nih.gov/35205633/

[8] "GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine" R. Ferro, A. Adamska, R. Lattanzio, I. Mavrommati, C. E. Edling, S. A. Arifin, C. A. Fyffe, G. Sala, L. Sacchetto, G. Chiorino, V. De Laurenzi, M. Piantelli, O. J. Sansom, T. Maffucci & M. Falasca https://www.nature.com/articles/s41388-018-0390-1

[9] "Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer" Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, Lorenzo Corsi https://pubmed.ncbi.nlm.nih.gov/30627539/

[10] "Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus" EM Rock, D Bolognini, CL Limebeer, MG Cascio, S Anavi-Goffer, S Anavi-Goffer, PJ Fletcher, PJ Fletcher, R Mechoulam, RG Pertwee, and LA Parker  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423241/

[11] "Hypnotic and antiepileptic effects of cannabidiol" E A Carlini, J M Cunha https://pubmed.ncbi.nlm.nih.gov/7028792/

[12] "Dogs as a Natural Animal Model of Epilepsy" Wolfgang Löscher https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257283/

[13] "Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Safety in Clinical Trials" Serena Silvestro, Santa Mammana, Eugenio Cavalli, Placido Bramanti, and Emanuela Mazzon https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514832/

[14] "Cannabinoids and Epilepsy" Evan C. Rosenberg, Richard W. Tsien, Benjamin J. Whalley, and Orrin Devinsk https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604191/

[15] Epidyolex 100 mg/ml oral solution https://www.medicines.org.uk/emc/product/10781#ORIGINAL

[16] "Cannabidiol blocks long-lasting behavioural consequences of predator threat stress: possible involvement of 5HT1A receptors" Alline Cristina Campos, Frederico Rogério Ferreira, Francisco Silveira Guimarães https://pubmed.ncbi.nlm.nih.gov/22979992/  

[17] "Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors" TV Zanelati, C Biojone, FA Moreira, FS Guimarães, and SRL Joca https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823358/

[18] "Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis" Federica Alessandra Brioschi, Federica Di Cesare, Daniela Gioeni, Vanessa Rabbogliatti, Francesco Ferrari, Elisa Silvia D'Urso, Martina Amari, and Giuliano Ravasio https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552307/

[19] "Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood" Enrico Gugliandolo, Patrizia Licata, Alessio Filippo Peritore, Rosalba Siracusa, Ramona D'Amico, Marika Cordaro, Roberta Fusco, Daniela Impellizzeri, Rosanna Di Paola Salvatore Cuzzocrea, Rosalia Crupi, and Claudia Dina Interlandi https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473042/

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